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Topic 5 and 6 Bio

What is Metabolism?

Totality of an organism's chemical reactions

What does a metabolic pathway begin and end with?

It begins with a specific molecule and ends with a product

Is each step catalyzed by a specific enzyme?

Yes

How do Catabolic Pathways release energy?

They release energy by breaking down complex molecules into similar compounds

Describe an anabolic pathway

They consume energy to build complex molecules from simpler ones

What is an example of an anabolic pathway?

Protein synthesis from amino acids

What are bioenergetics?

The study of how organisms manage their energy resources

Kinetic energy is associated with________

Motion

Heat (thermal energy) is __________________________________________

kinetic energy associated with random movement of atoms or molecules

Potential Energy is _________________________

Energy that matter possesses because of its location or structure

Chemical Energy is _______________

Potential energy availabe released in a chemical reaction

How do spontaneous processes occur?

Without energy input and happen quickly

What is a living systems "free energy"

energy that can do work when temp and pressure and uniform, such as in a living cell

Exergonic reactions __________ free energy and is ________

release and spontaneous

Endergonic reactions ___________ free energy and is ________________

absorbs, nonspontaneous

Energy coupling in cells is mediated by ___

ATP

What is energy coupling?

Cells manage energy resources by energy coupling, or the use of a exergonic process to drive an endergonic one

What is ATP composed of?

a ribose (sugar), adenine (nitrogenous base), and three phosphate groups

How is energy released from ATP?

When the terminal phosphate bond is broken

What is a catylist?

Chemical agent that speeds up a reaction

What is an enzyme

Catalytic protein

The initial energy needed to start a chemical reaction is what

Activatio Energy

How do enzymes catalyze reactions?

By lowering the activation energy barrier

What is a substrate?

It is what an enzyme acts on

What is created when an enzyme binds to its subsrate?

Enzyme-substrate complex

What is an active site?

The region where the substrate binds to an enzyme

What does induced fit do?

Brings chemical groups of the active site into positions that enhance their ability to catalyze the reaction

How can the active site lower EA?

Through orienting substrates correctly, straining substrate bonds, providing a favourable microenvironment, covalently bonding to a substrate

What are some factors that effect enzymes?

Temperature and pH, and certain chemicals can influence the enzyme

How does temperature and pH affect an enzyme?

It affects the shape, thus affecting the enzymes ability to function

What are cofactors?

Nonprotein enzyme helpers

What is an organic cofactor called?

An organic cofactor is alled a coenzyme

What is competative inhibition?

Inhibitors that bind to the active site

What is noncompetative inhibition?

Bind to another part of the enzyme, leading to the enzyme changing shape

What are some examples of inhibitors?

Toxins, poisons, pesticides, and antibodies

What is feedback inhibition?

When the end product of a metabolic pathway shuts down the pahway

How is feedback inhibition benefictal?

Prevents a cell from wasting chemical resources by synthesizing more product than what is needed

Enzymes need for cellular respiration are housed where?

In the mitochondria

Is the breakdown of organic molecules exergonic or endogonic?

Exogonic

What does fermentation occur without?

Oxygen

What does Aerobic respiration consume that Anaerobic respiration does not?

Oxygen

What do aerobic and anerobic respiration both yield?

ATP

Electrons from organic compounds are usually first transfered to _______, a coenzyme

NAD+, becoming NADH

Where does NADH pass electrons?

To the electron transport chain

How is energy gained from the ETC?

Oxygen pulls electrons down the chain in an energy yielding tumble, the energy yielded is used to regenerate ATP

What are the three phases of Cellular Respiration?

Glycolysis, The Citric Acid Cycle, and Oxidative phosphorylation

What does gycolysis do?

Breaks down glucose into two molcules of pyruvate

How many molecules of pyruvate are created from glycolysis?

Two

What does the citric acid cycle do?

Completes the breakdown of glucose

Where does The Citric Acid Cycle take place?

In the mitochondria

What process generates the most ATP?

Oxidative phosphorylation

What is subsrate-level phosphorylation?

The smaller amount of ATP is formed in glycolysis and the citric acid cyclr

What is glycolysis?

The splitting of sugar, breaking down glucose into 2 pyruvate molecules

Where does glycolysis occur?

In the cytoplasm

What are the two phases of Glycolysis?

Energy Investment and Energy Payoff

How much ATP is created from Glycolysis

Net increase of 2

How does pyruvate enter the mitochondria?

Through coenzyme A

What is pyruvate converted into?

Acetyl CoA

What does the Krebs cycle do?

Breaks down pyruvate to CO2

Where is the ETC located?

In the inner membrance of the mitochondrion (cristae)

What is proton-motive force?

The H+ gradient, emphasizing its capacity to do work

During CR how does energy flow?

Glucose --> NADH --> ETC --> Proton-motive force --> ATP

How many ATP are made from one glucose molecule?

32

Without Oxygen what ceases to function?

The ETC

What are the two types of fermentation

Alcohol and lactic acid fermentation

In alcohol fermentation, pyruvate is converted to what in 2 steps?

Ethanol, and releases CO2

What is formed in lactic acid fermentation?

Lactate, with no CO2 released

What are obligate anaerobes?

Carry out fermentation and cannot survive in the presence of oxygen

What are faculatative anaerobes?

Can survuve using either fermentaino or cellular respiration

beta oxidation breaks down fatty acids and yield ________

acetyl CoA

Fats are digested to ________ used in glycolysis

glycerol

How is cellular respiration regulated?

Through feedback inhibition

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