male reproductive system
what are the hormone that control the male reproductive system
• FSH, follicle-stimulating hormone.
• GnRH gonadotrophin-releasing hormone.
• ICSH, interstitial cell-stimulating hormone.
which hormone control the secretion of gonadotrophins by the anterior pituitary
GnRH
which hormone is responsible for for the integrity of the seminiferous tubules
FSH
which hormone controls the secretion of testosterone
LH
which hormone is the active form of androgen
5α-dihydrotestosterone which is metabolite from testosterone and responsible of androgenic action
why testosterone is the mostimportant andrigens and where it is synthesised?
because it is the natural androgen in humans
Synthesised in:
• Leydig cells of the testes in males.
• Ovaries in females (small amount)
• Adrenal gland (both sexual)
why do we want do administer androgen to male at buperty?
Hypogonadism. There is no maturation of the male genetic organs so it may be a problem in the hypothalamus, so the testosterone is not produced.
what is the causes of hypogonadism
it may be primary hypogonadism due to testicular dysfunction.
or secondary hypogonadism due to dailure of the hypotalamus or pituitary.
in aging there is a sharp drop in testetosterone hormone in males like the oestrogen hormone in female (true/false)
false
which protein does the testosterone binds to in the blood
albumin and androgen binding pretein in sertoli cells
what is the main organ for breakdownof testosterone
liver
what is the anti-andrigen used for?
used in the treatment of patients producing excessive amounts of testosterone
give me 4 anti-androgens and explain the action of each one
Cyproterone: It is a partial agonist at androgen receptors, competing with dihydrotestosterone for receptors in androgen-sensitive target tissues
– Used as part of treatment of prostatic cancer
Finasteride:inhibits the enzyme (5α-reductase) enzyme that converts testosterone to dihydrotestosterone
– Used in benign prostatic hypertrophy (enlarged prostate)
Flutamide:acts as competitive inhibitor of androgens at
target cells.
– Used as part of treatment of prostatic cancer.
Ketoconazole: used primarily in the treatment of fungal disease, is an inhibitor of adrenal and gonadal steroid synthesis.
what drugs can cause infertillity
sulfasalazine, an anti-inflammatory drug for rheumatoid arthritis