Imuno
Funcao cell NK
Intra cell, libera granzimas e perforinas, Il-12,IL-15, INF-y
Funcao cell Basofilo
IL-3,Alergia,Histamina
Eosinofilo
IL-5, Alergia,helminto
Neutrofilo
Bac extracell, inflamacao
Mastocito
desgranula histamina e heparina, IL-3
IgM
Primeiro formado em infeccao recente, ativa SC
IgG
Infeccao prologada, atravessa placenta
IgE
Alergia, helmintos, sensibiliza mastocitos
Diferenciacao Linf T
Th1 ,Th2 , Th17 , Treg
Th1
Alvo : Virus , patogenos intracell
Produz : IFN-Y
Resposta :
- expressao de MHC II --> Maior apresentacao --> maior resp imune
- Mais enzimas --> mais morte de patogenos fagocitados
- Mais producao de IL-1, TNF-a, IL-12
IL-1
Origem : macrofagos, cell dendriticas, monocitos (Th1&TH2).
- estimula resp inf
- sintese de prot em fase aguda
- Promove mais cell TH2
IL-2
Origem : Th1
- fator de crecimento cell T,cell B, NK, Macrofagos
INF-Y
Origem : Th1
- Ativa NK e Macrofagos
- Inibe cell TCD4 Th2
- Inzud expressao de MHC2
IL-4
Origem : Th2, TCD4,Mastocitos
- fator de crecimento cell B e cell TCD4 Th2
- Promove sintese de IgE e IgG
- resp alergica e Helmintos
- Inibe cell TCD4 Th1
IL-5
Origem : Th2 e mastocitos
- estimula crecimento de cell B
- aumenta secrecao de anticorpos
- fator de crecimento e diferenciacao de eosinofilos
- ativa eosinofilos
IL-6
- age em conjunto com IL-4 para promover diferenciacao de Th2
- aumenta producao de IL-2
- Aumenta anticorpos pelas cell B ativadas
- Estimula diferenciacao de YCD4 em Th1
IL-10
Origem: Th2
- inibe funcao Th1
- Imunosupressor da funcao de macrofagos e IL-12 e de MHC II
IL-12
Origem : macrofago
- Ativa cell NK
- mediador da resp inata a MO intracell
- estimula producao de INF-Y
- Potencializa funcao da NK e TCD8
- Reduz producao de IgE supremindo sinrtese de IL-4
- estimula diferenciacao de TCD4 naive para cells efetora Th1
IL-13
Origem: Th2,TCD8,NK
- Imunosupressor
- alergia e helmito
- crecimento de cell B
- suprime funcao de macrofago
- secrecso de muco
IL-15
Origem: monocitos
alvo:Linf T e B ativados
- Aumenta TCD8
- Ativa NK
IL-17
origem:TCD4
- estimula quimiocinas e inflamacao
INF-1 (a&b)
- infecao viral
- origem : cell dendriticas
- inibe replicacao viral induzindo estado anti viral nas cells vizinhas
- lesao tecidual no local da infecao
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p.s. je hoeft er niet bij te zetten of woorden mannelijk of vrouwelijk zijn als er les, of l' staat. :) |
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p.s. je hoeft er niet bij te zetten of woorden mannelijk of vrouwelijk zijn als er les, of l' staat. :) |
| öva mera på |
| 4.4 (Frans naar Nederlands)Als ik spelfouten heb gemaakt, laat maar weten.
p.s. je hoeft er niet bij te zetten of woorden mannelijk of vrouwelijk zijn als er les, of l' staat. :) |
| 4.2 (Frans naar Nederlands)Als ik spelfouten heb gemaakt, laat maar weten.
p.s. je hoeft er niet bij te zetten of woorden mannelijk of vrouwelijk zijn als er les, of l' staat. :) |
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| 4.1 (Frans naar Nederlands)Als ik spelfouten heb gemaakt, laat maar weten.
p.s. je hoeft er niet bij te zetten of woorden mannelijk of vrouwelijk zijn als er les, of l' staat. :) |
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