deel 11
Ass
k0/ke
Css (continuous IV infusion 1CMT)
k0/ke•Vd = k0/CL = D/CL • τ
loading dose
Css•Vd
Css (2CMT)
k0/β•Vdβ
fluctuation depends on
ke
τ
loading dose use
to reach the equilibrium value immediately (SS)
D* = A ∞ max (bij SS)
dose proportionality
slope 45°
superposition principle
doubling of dose = doubling of concentrations