pcol2 unitB
reduce preload and myocardial wall tension, thereby decreasing oxygen demand
Nitrates and Nitrites
relax arteries, decreasing afterload. They are the drug of choice for Prinzmetal (variant) angina
Dihydropyridines (DHPs)
reduce heart rate and contraction, lowering the heart's oxygen demand
Non-dihydropyridines
reduce oxygen demand by decreasing heart rate and myocardial contractility
beta blockers
inhibits the "funny" channel pacemaker current (If) in the sinoatrial node, which is a key mechanism for heart rate control. By slowing the heart rate, it decreases oxygen demand and increases perfusion time in the coronary arteries, thereby improving oxygen delivery
ivabradine
blocking a late sodium current, which in turn reduces the entry of calcium into the heart muscle cells via the sodium-calcium exchanger. This action prevents elevated intracellular calcium, which leads to increased diastolic tension, impaired relaxation, and higher oxygen consumption
Ranolazine
inhibits the enzyme ketoacyl coA thiolase, which is involved in fatty acid oxidation for energy production
Trimetazidine
These drugs, such as aspirin, ticlopidine, and clopidogrel, are used to prevent or remove blood clots (thrombi and emboli).
Antiplatelet Agents