2535 week 7- pharma
What is the first line of defense
Surface barriers that prvent pathogen entry
1) Physical- skin, mucous membranes
2) Chemical- vaginal secretions, saliva
What is the second line of defense
Non specific attack
consists of leukocytes
compromises innate immunity
what is the third line of defense
Specific attack on pathogens
production of AB, lymphocytes
Targets adaptive immunity
Three types of organ rejection
1) Hyperacute: immediate inflammatory response within mins-hrs
2) Acute- Within 3 mths
mediated by macrophages and T-cytotoxic cells
often reversible with immunosupressant drugs
3) Chronic- months to a year
Non treatable and irreversivle
low grade B & T-cell mediated response
Immunosupressant Drug types
1) Glucocorticoids- inhibits all stages of T-cell production and used for induction
2) Calcineum inhibitors- inhibit phosphate procuction for INK2 production
3) Biologics- Inhibit T-cytotoxic & TNK cells
4) Antimetabolic- Inhibits cell poliferation
Define active immunization & two types
AAI- Body is clinically exposed to harmless antigen that does not cause infection but body stores info of AT ready to resist in the future
NAI- Pt acquires immunity by surviving the disease and producing AB