sympathoplegic drugs
Agents that alter the response of sympathetic nervous systems by inhibiting neurotransmitter outflow OR blocking the binding of NE and Epi in adrenergic receptors
Sympathoplegic drugs
agents of α1-Adrenoceptor Antagonists
Doxazosin, Prazosin, Terazosin
not recommended as initial treatment of hypertension
α1-Adrenoceptor Antagonists
useful in treating patients with Benigh Prostatic Hyperplasia (enlarged prostate) as symptomatic treatment
α1-Adrenoceptor Antagonists
Blocks the β1 receptors in the heart → ↓HR and contractility
Beta Adrenoceptor Antagonists
These agents are also not usually used as first line but used in patients with other CVD
Beta Adrenoceptor Antagonists
These agents can be used in patients with hypertension and asthma.
Beta-1 Selective Adrenoceptor Antagonists
These agents cannot be used in patients with hypertension and asthma.
non selective and mixed
These agents can enter the blood-brain-barrier
Lipophilic Beta-blockers
agents of Lipophilic Beta-blockers
Propranolol, Metoprolol, Labetalol
Due to their lipophilicity, these agents can be used as prophylaxis for migraine, specifically
propranolol
has potassium channel blocking properties in high doses
sotalol
agents of Polar Beta-blockers
atenolol, nadolol, sotalol
These agents can block Na channels and can induce “weak” local anesthetic effects
Beta-blockers with Membrane Stabilizing Activity
side effects of methyldopa
Coomb’s positive Hemolytic anemia
used in HTN crisis and as non-stimulant agent for ADHD
clonidine
used as non-stimulant agent for ADHD
guanfacine