vasodilators

useful in hypertension as they relax the arterioles decreasing peripheral vascular resistance

vasodilators

for long-term outpatient therapy

oral vasodilators

ex. of oral vasodilators

Hydralazine and Minoxidil

ex. of parenteral vasodilators

nitroprusside, diazoxide, and fenoldopam

Reduce the Ca2+ influx in the blood vessels resulting to relaxation and dilation of vascular smooth muscle

Calcium Channel Blockers

not used in HTN but useful in sub-arachnoid hemorrhage or stroke

nimodipine

Release of nitric oxide

hydralazine

for Pregnant women and resistant hypertension

hydralazine

Hyperpolarization of smooth muscle membrane through opening of potassium channels

minoxidil

diazoxide

used for resistant hypertension

minoxidil

Hyperpolarization of smooth muscle membrane through opening of potassium channels

diazoxide

minoxidil

a condition which causes hypoglycemia

insulinoma

use for HTN crisis

nitroprusside

Activation of Dopamine-1 receptors

fenoldopam

inhibit the production of renin

aliskiren

toxic effect of aliskiren

renal toxicity

decrease angiotensinogen synthesis in the liver by reducing angiotensinogen mRNA levels

zilebesiran

hypertension in pregnancy

Methyldopa, Hydralazine, Labetalol, Nifedipine

side effects of hydralazine

systemic lupus erythematusus

side effects of diazoxide

hyperglycemia