EUKARYOTIC GENE REGULATION
molecules that bind to the promoters to initiate transcription
TRANSCRIPTION FACTORS
if TF is not reqquired, where is it located
CYTOPLASM
2 ways of binding regulation
ALTERATION OF DNA DOMAIN AND MULTIMERIZATION
a portion of TF that binds to the DNA
DNAA BINDING DOMAINN
process where a TF needs another TF to form a complex in order to be able to bind to the TF in the promoter
MULTIMERIZATION
it turns on transcription
ACTIVATOR
2 domains of the activator
DNA BINDING DOMAIN AND ACTIVATION DOMAIN
what are then2 processes in activation
LONG AND SHORT DISTANCE ACTIVATION
explain short distance enhancer
DNA BINDING DOMAIN WILL BIND TO THE ENHANCER DNA LOCATED BESIDE THE PROMOTER. AACTIVATION DOMAIN WILL FFACILITATE THE ASSEMBLY AND BINDING OF TF COMPLEX TO THE RNA POLYMERASE IN THE PROMOTER.
explain long distance activation
DNA BINDING DOMAIN WILL BIND TO THEE ENHANCER DNA LOCATED FAR FROM THE PROMOTER. DNA WILL UNDERGO LOOPING TO DELIVER THE ACTIVATOR NEAR THE TF COMPLEX FOR ACTIVATION.
it turns of the transcription
REPRESSOR
3 steps in transcription (kahit ano)
-REPRESSOR BINDS TO THE PROMOOTER TO PREVENTT THE TF COMPLEX FROM BINDING
-REPRESSOR BINDS TO THE ENHANCER TO PREVENT THE ACTIVATOR FROM BINDING
-REPRESSOR BINDS TO THE SILENCER GENE WITH ITS DNA BINDING DOMAIN CAUSING THE DNA TO UNDERGO LOOPING , BRINGING THE REPRESSION DOMAIN CLOSE TO THE PROMOTER.
they are non-coding RNAs with 20-24 nucleotides respomsible for the lifespaan of the mRNAs and bind to the mRNAs that arent translated
MICRO RNAs
what will happen if the nucleotide sequence is complementary to the segment of the mRNA
MRNA WILL BE CHOPPED AND DISCARDED