pcol unit2
produce from decarboxylation of L-histidine by histidine decarboxylase
histamines
organ in histamin 1 cause bronchoconstriction
lungs
cause increase gastric acid secretion receptor:
histamine 2
brain problems in nerve endings and brain receptor:
histamine 3
blockade of histamine in binding to H1 receptor resulting to effects opposite og H1 receptor stimulation.
Histamine 1 receptor blockers
blockade of histamine in binding to H2 receptors resulting to decreased gastric acid secretion
histamine 2 receptor blockers
least potent agents in histamine2 receptor
cimetidine
almost 100% bioavailability in histamine 2 receptors
nizatidine
3rd gen non sedating
fexofenadine norastemizole
brain:anxiolytic:
5HT1A
Blood vessel: vasoconstriction:
5HT1B/1D
BRAIN : HALLUCINATIONS
5HT2
TRIGGERZONE : VOMITING :
5HT3
GIT: PERISTALSIS
5HT4
STIMULATE VASOCONSTRICTION
5HT1B/1D
treatment for anxiety
buspirone
decrease 5ht transmission in brain
5HT2
induce peristalsis
5HT4
decrease the gastric acid secretion in gastric parietal cells
histamine 2
less endocrine effect
ranitidine